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Jeremy M. Baskin

Assistant Professor

Jeremy M. Baskin

Weill Hall, Room 461
G60 ST Olin
jeremy.baskin@cornell.edu
607-255-2887

Educational Background

  • Postdoc, Yale University
  • PhD, University of California, Berkeley
  • BS, Massachusetts Institute of Technology

Website(s)

Overview

My research interests center on pioneering innovative chemical approaches to probe the cell biology of diverse classes of lipids, with a major focus on developing new molecular imaging methods.

Keywords

Biochemistry, Cell Biology, Chemical Biology, Imaging Probes, Lipids and Membranes

Departments/Programs

  • Chemistry and Chemical Biology

Graduate Fields

  • Chemistry and Chemical Biology
  • Biochemistry, Molecular and Cell Biology

Affiliations

  • Weill Institute for Cell and Molecular Biology

Research

Lipids are a diverse group of metabolites that function as energy stores, components of membranes, and signaling molecules, and dysregulation of lipid metabolism occurs in many diseases. While lipids have been traditionally studied using in vitro or genetic techniques, chemical biology approaches can enable the rapid and precise interrogation of lipid biology within living systems. Research in my laboratory centers on the chemical biology and cell biology of lipids and biological membranes. Our work encompasses both methodology development and hypothesis-driven, mechanistic research aimed at shedding light on how lipid properties such as structure and subcellular location impact biological function. Using cross-disciplinary approaches, we are focused on elucidating signaling functions of lipid second messengers including phosphatidic acid and phosphoinositides. A vital part of my research program involves development of innovative chemical imaging tools to monitor these individual lipid species, notably a technique for imaging phosphatidic acid production by phospholipase D enzymes termed IMPACT. Separately, we are revealing new roles for phosphoinositides in the regulation of ubiquitination and Wnt signaling through our studies of a new family of lipid-binding proteins. Knowledge obtained from our foundational studies and initial applications of our tools has inspired novel directions of inquiry into fundamental biological mechanisms and those relevant to several human diseases, including multiple sclerosis and several cancers.

Courses

Publications

Baskin Lab Publications at Cornell:

Selected Publications, Reviews, and Patents from Graduate & Postdoctoral Work: