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Brian Crane

George W. and Grace L. Todd Professor

Brian Crane

Physical Sciences Building, Room 336
122 Baker Laboratory

Educational Background

  • PhD, The Scripps Research Institute
  • BSc, University of Manitoba



The Crane group studies structure, function and mechanism of protein systems that underlie signal transduction. Of particular emphasis are processes mediated by redox and photochemistry and those dependent on highly cooperative macromolecular assemblies. Projects include understanding circadian clock light sensors, bacterial transmembrane signaling, nitric oxide enzymology and general aspects of protein electron transfer.


Protein electron transfer reactions, photochemistry, nitric oxide and nitration in biological systems


  • Chemistry and Chemical Biology

Graduate Fields

  • Biochemistry, Molecular and Cell Biology
  • Biophysics
  • Chemistry and Chemical Biology
  • Pharmacology
  • Tri-Institutional Training Program in Chemical Biology (TPCB)


  • Understanding interactions among proteins, electrons, and photons
  • How metalloenzymes stabilize transient intermediates during catalysis
  • How protein structure controls long-range electron transfer
  • How photo and redox processes are used in biological information transfer
  • Combine genetic and chemical manipulation of proteins, atomic-resolution structure determination, and novel photochemically triggered experiments in single crystals
  • Understanding How Structure Controls Electron Transfer and Activated States in Metalloenzymes
  • Bacterial Nitric Oxide Synthases:
  • Light and Redox Sensing
  • Bacterial Chemotaxis


Fall 2021