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- Chemistry and Chemical Biology
Research in the Lambert group is focused in the area of catalysis. We are especially interested in the development of novel catalytic strategies for selective organic synthesis. Projects that we have been active in include dehydrative reactions, enantioselective Bronsted base catalysis, and carbonyl-olefin metathesis. In approaching these and other problems, we strive to develop highly effective practical solutions while asking interesting questions of reactivity and mechanism. We bring both synthetic and physical organic techniques to bear on answering these questions as we work to develop catalyst systems of practical value for the field of organic synthesis.
- Methods for the Synthesis of Functionalized Pentacarboxycyclopentadienes. Gheewala, C. D.; Radtke, M. A.; Hui, J.; Hon, A. B.; Lambert, T. H. Org. Lett. 2017, 19, 4227-4230.
- Polymer ClickabILs: Clickable Cyclopropenium Ionic Liquids. Freyer, J. L.; Gobieski, G. S.; Russell, S. T.; Sun, M.; Chen, Z.; Jiang, Y.; Bandar, J. S.; Lambert, T. H.; Campos, L. M. Angew. Chem. Int. Ed. 2016, 55, 12382-12386.
- Macrosteres: the Deltic Guanidinium Ion. Mishiro, K.; Lambert, T. H. Eur. J. Org. Chem. 2016, 1655-1659.
- An Aromatic Ion Platform for Enantioselective Brønsted Acid Catalysis. Gheewala, C. D.; Collins, B. E.; Lambert, T. H. Science, 2016, 351, 961-965.
- Higher-Order Cyclopropenimine Superbases. Nacsa, E. D.; Lambert, T. H. 2015, J. Am. Chem. Soc. 2015, 137, 10246-10253.
- The Evolution of Cyclopropenium Ions Into Functional Polyelectrolytes. Jiang, Y.; Freyer, J. L.; Cotanda, P.; Brucks, S. D.; Killops, K. L.; Bandar, J. S.; Torsitano, C.; Balsara, N. P.; Lambert, T. H.; Campos, L. M. Nature Commun. 2015, 6, 5950-5956.