Tristan Lambert

William T. Miller Professor of Chemistry

Research Focus

Research in the Lambert group is focused in the area of catalysis.  We are especially interested in the development of novel catalytic strategies for selective organic synthesis. Projects that we have been active in include electrophotocatalysis, catalytic carbonyl-olefin metathesis, and the study of aromatic ions.  In approaching these and other problems, we strive to develop highly effective practical solutions while asking interesting questions of reactivity and mechanism.  We bring both synthetic and physical organic techniques to bear on answering these questions as we work to develop catalyst systems of practical value for the field of organic synthesis.

Publications

  • Cross-Coupling of Amines via Photocatalytic Denitrogenation of In Situ-Generated Diazenes. Steiniger, K. A.; Lamb, M. C.; Lambert, T. H. J. Am. Chem. Soc. 2023, 145, 11524-11529.
  • Olefination of Carbonyls with Alkenes Enabled by Electrophotocatalytic Generation of Distonic Radical Cations. Steiniger, K. A.; Lambert, T. H. Science Adv. 20239, eadg3026.
  • Electrophotocatalytic Oxygenation of Multiple Contiguous Adjacent C–H Bonds. Shen, T.; Li, Y.-L.; Ye, K.-Y.; Lambert, T. H. Nature 2023614, 275-280.
  • Ring-opening Metathesis Polymerization Using Hydrazonium Initiators. Quach, P.; Hsu, J. H.; Keresztes, I.; Fors, B. P.; Lambert, T. H. Angew. Chem. Int. Ed. 2022, 61, e202203344.
  • Electrophotocatalytic Diamination of Vicinal C–H Bonds. Science 2021, 371, 620-626.
  • Reductive Electrophotocatalysis: Merging Electricity and Light to Achieve Extreme Reduction Potentials. Kim, H.; Kim, H.; Lambert, T. H.; Lin, S. J. Am. Chem. Soc. 2020, 142, 2087-2092.
  • Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication. Huang, H.; Strater, Z. M.; Rauch, M.; Shee, J.; Sisto, T. J.; Nuckolls, C.; Lambert, T. H. Angew. Chem. Int. Ed. 2019, 58, 13318-13322.
  • An Aromatic Ion Platform for Enantioselective Brønsted Acid Catalysis.  Gheewala, C. D.; Collins, B. E.; Lambert, T. H. Science 2016, 351, 961-965.

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