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Yimon Aye

Howard Milstein Faculty Fellow and Assistant Professor

Baker Laboratory, Room 244a
ya222@cornell.edu
607-254-4519

Educational Background

  • Damon Runyon Postdoc Fellow, Massachusetts Institute of Technology (2009-2012)
  • PhD, Harvard University (2009)
  • M.Chem, University of Oxford (2004)
  • B.Chem, University of Oxford (2003)

Overview

Note to applicants for positions in the Aye Lab: Following lab promotion, we are very excited to be moving to join EPFL in the near future ISIC EPFL -- home of the Aye Lab Business will be uninterrupted as almost all of the team members are coming along. We are happy to have spent our formative years at Cornell and Weill Cornell Medicine.

Innovation and applications of novel tools to interrogate cell signaling; Mechanisms of proteins/pathways involved in genome protection and drugs that tap into these pathways. Please visit our lab website for more information.

Keywords

Selected Honors: Beckman Young Investigator (2014); NSF CAREER (2014); NIH Director's New Innovator (2014); Sloan Fellowship (2016); American Chemical Society CRT Young Investigator (2016); American Chemical Society WCC Rising Star Chemist (2016); International Chemical Biology Society Rising Star Chemical Biologist (2016); Office of Naval Research Young Investigator (2017); Pershing Square Sohn Prize in Cancer Research (2017); American Chemical Society Buck-Whitney Award (2017)

Departments/Programs

  • Chemistry and Chemical Biology

Graduate Fields

  • Biochemistry, Molecular and Cell Biology
  • Biophysics
  • Chemistry and Chemical Biology

Affiliations

  • Weill Cornell Medicine, Department of Biochemistry

Research

The Aye Lab (established: July 2012) exploits a unique blend of chemical biology methods development, mechanistic biochemistry, mammalian cell biology as in vitro research toolkit and worm and fish as in vivo models.

Courses

Publications

From the Aye Lab (est. July 2012)

(*correspondence author)

  • Original Research

Yi Zhao, Marcus J. C. Long, Yiran Wang, Sheng Zhang, and Yimon Aye* "Ube2V2 is a Rosetta Stone bridging redox and ubiquitin codes, coordinating DNA damage responses"

ACS Central Science 2018 4, 246–259

  • Problems and Paradigms

Jesse R. Poganik, Marcus J. C. Long, and Yimon Aye* "Getting the message? Native reactive electrophiles pass two out of three thresholds to be bona fide signaling mediators"

BioEssays 2018 Just Accepted (doi:10.1002/bies.201700240)

  • Original Research

Sanjna L. Surya, Marcus J. C. Long, Daniel A. Urul, Yi Zhao, Emily J. Mercer, Islam M. Elsaid, Todd Evans, and Yimon Aye* "Cardiovascular small heat shock protein HSPB7 is a kinetically-privileged RES sensor"

ACS Chemical Biology 2018 Just Accepted (doi: 10.1021/acschembio)

* Invited contribution to "Biosensors" special issue

  • Protocols

Alexandra Van Hall-Beauvais, Yi Zhao, Daniel A. Urul, Marcus J. C. Long, and Yimon Aye* "Single-protein-specific redox targeting in live mammalian cells and C. elegans"

Current Protocols in Chemical Biology 2018 Just Accepted (doi:10.1002/cpch.43)

  • Original Research

Marcus J. C. Long, Daniel A. Urul, Shivansh Chawla, Hong-Yu Lin, Yi Zhao, Joseph A. Haegele, Yiran Wang, and Yimon Aye* "Precision Electrophile Tagging in Caenorhabditis elegans"

Biochemistry 2018 57, 216–220

* Invited contribution to "Future of Biochemistry" special issue

* Selected as an ACS Editors' Choice article.

  • Original Research

Marcus J. C. Long, Hong-Yu Lin, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, and Yimon Aye* "β-TrCP1 is a Vacillatory Regulator of Wnt Signaling"

Cell Chemical Biology 2017 24, 944–957

  • Perspective

Marcus J. C. Long, and Yimon Aye* "Privileged Electrophile Sensors: a Resource for Covalent Drug Development"

Cell Chemical Biology 2017 24, 787–800

  • Original Research

Marcus J. C. Long, Saba Parvez, Yi Zhao, Yiran Wang, Sanjna L. Surya, and Yimon Aye* "Akt3 is a Privileged First Responder in Isozyme-Specific Electrophile Response"

Nature Chemical Biology 2017 13, 333–338

*Highlighted for “News & Views”: Nature Chemical Biology 2017 13, 244–245

  • Review Article

Marcus J. C. Long, Souradyuti Ghosh, Jesse R. Poganik, and Yimon Aye*Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology.”

ACS Chemical Biology 2017 12, 586–600

  • Original Research

Saba Parvez, Marcus J. C. Long, Hong-Yu Lin, Yi Zhao, Joseph A. Haegele, Vanha N. Pham, Dustin K. Lee, and Yimon Aye* “T-REX™ On-Demand Redox Targeting in Live Cells

Nature Protocols 2016 11, 2328–2356

  • Perspective

Marcus J. C. Long, and Yimon Aye*The Die is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision Making

ACS Chem Res Toxicol 2016 29, 1575–1582

* Contributed as part of 2016 ACS CRT Young Investigator Award to Y.A.

* Selected as an ACS Editors' Choice article.

* Selected for Journal Cover Art.

  • Original Research

Somsinee Wisitpatthaya, Yi Zhao, Marcus J. C. Long, Minxing Li, William A. Blessing, Elaine A. Fletcher, Robert S. Weiss, and Yimon Aye* “Antileukemic Nucleotides Induce Conformationally Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition

ACS Chemical Biology 2016 11, 2021–2032

  • Perspective

Marcus J. C. Long, Jesse R. Poganik, and Yimon Aye*On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry

J Am Chem Soc 2016, 138, 3610–3622

         *Selected as a JACS Spotlights Article 2016, 138, 4269

         * The ACS LiveSlides Open Access Article

  • Original Research

Hong-Yu Lin, Joseph A. Haegele, Michael T. Disare, and Yimon Aye* “A Generalizable Platform for Interrogating Target- and Signal-Specific Consequences of Electrophilic Modifications in Redox-Dependent Cell Signaling

J Am Chem Soc (Full Article) 2015, 137, 6232–6244

  • Original Research

Saba Parvez, Yuan Fu, Jiayang Li, Marcus J. C. Long, Hong-Yu Lin, Dustin K. Lee, Gene S. Hu and Yimon Aye* “Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant Response

J Am Chem Soc (Communication) 2015, 137, 10–13

  • Mini Review

Yimon Aye*, Minxing Li, Marcus J. C. Long and Robert Weiss* (*, co-corresponding authors) “Ribonucleotide Reductase & Cancer: Biological Mechanisms & Targeted Therapies

Oncogene (Mini Review) 2015, 34, 2011

  • Original Research

Yuan Fu, Hong-Yu Lin, Somsinee Wisitpitthaya, William A. Blessing and Yimon Aye* “A Fluorimetric Readout Reporting the Inhibitor-Induced Human Ribonucleotide Reductase Oligomerization

ChemBioChem (Full Article) 2014, 15, 2598–2604

  • Original Research

Yuan Fu, Marcus J. C. Long, Mike Rigney, Saba Parvez, William A. Blessing and Yimon Aye* “Uncoupling of Allosteric and Oligomeric Regulation in a Functional Hybrid Enzyme Constructed from Escherichia coli and Human Ribonucleotide Reductase

Biochemistry (Full Article) 2013, 52, 7050–7059

  • Original Research

Xinqiang Fang, Yuan Fu, Marcus J. C. Long, Joseph A. Haegele, Eva J. Ge, Saba Parvez and Yimon Aye*Temporally Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells

J Am Chem Soc (Communication) 2013, 135, 14496–14499

Postdoctoral (Aug 2009 - June 2012)

Original research:

Predoctoral (Jan 2005 - Jun 2009)

Independent review article:
Original research: