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Yimon Aye

Howard Milstein Faculty Fellow and Assistant Professor

Educational Background

  • Postdoc, Massachusetts Institute of Technology
  • PhD, Harvard University
  • University of Oxford

Website(s)

Overview

Methods development in deconstructing redox-dependent signal transduction; Molecular regulation of proteins/pathways involved in mammalian genome surveillance. Please visit our lab website for more information.

Keywords

Selected Honors: Beckman Young Investigator (2014); NSF CAREER (2014); NIH Director's New Innovator (2014); Sloan Fellowship (2016); American Chemical Society CRT Young Investigator (2016); American Chemical Society WCC Rising Star Chemist (2016); International Chemical Biology Society Rising Star Chemical Biologist (2016); Office of Naval Research Young Investigator (2017); Pershing Square Sohn Prize in Cancer Research (2017)

Departments/Programs

  • Chemistry and Chemical Biology

Graduate Fields

  • Biochemistry, Molecular and Cell Biology
  • Biophysics
  • Chemistry and Chemical Biology

Affiliations

  • Weill Cornell Medicine, Department of Biochemistry

Research

The Aye Lab (established: July 2012) exploits a unique blend of synthetic methodology, mechanistic biochemistry, mammalian cell biology as in vitro research toolkit and worm and fish as in vivo models.

Courses

Publications

Selected Publications: Aye Lab (est. July 2012) (*correspondence author)

14)     Original Research

Marcus J. C. Long, Hong-Yu Lin, Saba Parvez, Yi Zhao, Jesse R. Poganik, Paul Huang, and Yimon Aye* "β-TrCP1 is a Vacillatory Regulator of Wnt Signaling, Either Degrading β-Catenin or Preventing Nrf2 Inhibition of Wnt"

Cell Chemical Biology 2017 Just Accepted

13)     Perspective

Marcus J. C. Long, and Yimon Aye* "Privileged Electrophile Sensors: a Resource for Covalent Drug Development"

Cell Chemical Biology 2017 In Press

12)     Original Research

Marcus J. C. Long, Saba Parvez, Yi Zhao, Yiran Wang, Sanjna L. Surya, and Yimon Aye* "Akt3 is a Privileged First Responder in Isozyme-Specific Electrophile Response"

Nature Chemical Biology 2017 13, 333–338

*Highlighted for “News & Views”: Nature Chemical Biology 2017 13, 244–245

11)     Review Article

Marcus J. C. Long, Souradyuti Ghosh, Jesse R. Poganik, and Yimon Aye* “Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology.”

ACS Chemical Biology 2017 12, 586–600

10)  Original Research

Saba Parvez, Marcus J. C. Long, Hong-Yu Lin, Yi Zhao, Joseph A. Haegele, Vanha N. Pham, Dustin K. Lee, and Yimon Aye* “T-REX™ On-Demand Redox Targeting in Live Cells”

Nature Protocols 2016 11, 2328–2356

9)     Perspective

Marcus J. C. Long, and Yimon Aye* “The Die is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision Making”

ACS Chem Res Toxicol 2016 29, 1575–1582

* Contributed as part of 2016 ACS CRT Young Investigator Award to Y.A.

* Selected as an ACS Editors' Choice article.

* Selected for Journal Cover Art.

8)     Original Research

Somsinee Wisitpatthaya, Yi Zhao, Marcus J. C. Long, Minxing Li, William A. Blessing, Elaine A. Fletcher, Robert S. Weiss, and Yimon Aye* “Antileukemic Nucleotides Induce Conformationally Distinct Hexamers Defining a Common Mode of Reversible RNR Inhibition”

ACS Chemical Biology 2016 11, 2021–2032

7)     Perspective

Marcus J. C. Long, Jesse R. Poganik, and Yimon Aye* “On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry”

J Am Chem Soc 2016, 138, 3610–3622

         *JACS Spotlights Article – 2016, 138, 4269

         * The ACS LiveSlides Open Access Article

6)     Original Research

Hong-Yu Lin, Joseph A. Haegele, Michael T. Disare, and Yimon Aye* “A Generalizable Platform for Interrogating Target- and Signal-Specific Consequences of Electrophilic Modifications in Redox-Dependent Cell Signaling”

J Am Chem Soc (Full Article) 2015, 137, 6232–6244

5)     Original Research

Saba Parvez, Yuan Fu, Jiayang Li, Marcus J. C. Long, Hong-Yu Lin, Dustin K. Lee, Gene S. Hu and Yimon Aye* “Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant Response”

J Am Chem Soc (Communication) 2015, 137, 10–13

4)     Mini Review

Yimon Aye*, Minxing Li, Marcus J. C. Long and Robert Weiss* (*, co-corresponding authors) “Ribonucleotide Reductase & Cancer: Biological Mechanisms & Targeted Therapies”

Oncogene (Mini Review) 2015, 34, 2011

3)     Original Research

Yuan Fu, Hong-Yu Lin, Somsinee Wisitpitthaya, William A. Blessing and Yimon Aye* “A Fluorimetric Readout Reporting the Inhibitor-Induced Human Ribonucleotide Reductase Oligomerization”

ChemBioChem (Full Article) 2014, 15, 2598–2604

2)     Original Research

Yuan Fu, Marcus J. C. Long, Mike Rigney, Saba Parvez, William A. Blessing and Yimon Aye* “Uncoupling of Allosteric and Oligomeric Regulation in a Functional Hybrid Enzyme Constructed from Escherichia coli and Human Ribonucleotide Reductase”

Biochemistry (Full Article) 2013, 52, 7050–7059

1)     Original Research

Xinqiang Fang, Yuan Fu, Marcus J. C. Long, Joseph A. Haegele, Eva J. Ge, Saba Parvez and Yimon Aye* “Temporally Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells”

J Am Chem Soc (Communication) 2013, 135, 14496–14499

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Postdoctoral (Aug 2009 - June 2012)

Original research:

“Mechanistic Studies of Semicarbazone Triapine® Targeting on Ribonucleotide Reductase in Vitro and in Mammalian Cells: Tyrosyl Radical Quenching Not Involving Reactive Oxygen Species” Yimon Aye, Marcus J. C. Long and JoAnne Stubbe* J Biol Chem 2012, 287, 35768.

“Clofarabine Targets the Large Subunit (a) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers” Yimon Aye, Edward J. Brignole, Marcus J. C. Long, Johnathan Chitturulu, Catherine L. Drennan, Francisco J. Asturias, and JoAnne Stubbe* Chem Biol 2012, 19, 799.

“Clofarabine 5´-Di and –Triphosphates Inhibit Human Ribonucleotide Reductase by Altering the Quaternary Structure of its Large Subunit” Yimon Aye and JoAnne Stubbe* Proc Natl Acad Sci USA 2011 direct submission, 108, 9815.

Predoctoral (Jan 2005 - Jun 2009)

Independent review article:

“Vinyl-, Propargyl- and Allenylsilicon Reagents in Asymmetric Synthesis: Relatively Untapped Resource of Environmentally-Benign Reagents” Marcus J. Curtis-¬Long and Yimon Aye*; Chemistry, A European Journal 2009, 15, 5402.

Original research:

“Structural Report for Sc[(R,R)-norephedrine-pybox](OTf)3 Dimeric Complex” Richard J. Staples* and Yimon Aye; Journal of Chemical Crystallography 2008, 38, 49.
 
“Aluminum-catalyzed Enantio- and Diastereoselective Carbonyl Addition of Propargylsilanes. A New Approach to Enantioenriched Vinyl Epoxides” David A. Evans* and Yimon Aye; Journal of the American Chemical Society 2007, 129, 9606.

“Enantioselective Scandium-catalyzed Vinylsilane Additions: A New Approach to the Synthesis of β,γ-Unsaturated α-Amino Acid Derivatives” David A. Evans* and Yimon Aye; Journal of the American Chemical Society 2006, 128, 11034.

“Asymmetric, Anti–selective Scandium-catalyzed Sakurai Additions to Glyoxamide. Applications to the Syntheses of N-Boc- D-Alloisoleucine and D-Isoleucine” David A. Evans*, Yimon Aye and Jimmy Wu; Organic Letters 2006, 8, 2071.

“Copper-catalyzed Asymmetric Conjugate Reduction as a Route to Novel β-Azaheterocyclic Acid Derivatives” Matthew P. Rainka, Yimon Aye and Stephen L. Buchwald*; Proceedings to the National Academy of Sciences USA, 2004, 101, 5821.