arrow grid linear view icon
The College of Arts Sciences Search

You are here

Hening Lin

Professor

PHYSICAL SCIENCES BUILDING, Room 287
hl379@cornell.edu
607-255-4650

Educational Background

  • Postdoc, Harvard Medical School
  • PhD, Columbia University
  • BS, Tsinghua University

Website(s)

Overview

The Lin Group, an HHMI chemical biology lab at Cornell,  studies the chemistry, biology, and application of enzymes that have important physiological functions with a combination of synthetic and biochemical methods.

Departments/Programs

  • Chemistry and Chemical Biology

Graduate Fields

  • Biochemistry, Molecular and Cell Biology
  • Chemistry and Chemical Biology
  • Microbiology
  • Pharmacology
  • Tri-Institutional Training Program in Chemical Biology (TPCB)

Research

  • The chemistry, biology, and application of enzymes
  • Enzymes of particular interest are sirtuins, HDACs, PARPs, radical SAM enzymes, and CD38. Most of these enzymes are involved in protein post-translational modifications and have important biological functions.
  • We combine organic synthesis, biochemistry, biophysics, molecular biology, and cell biology to study the enzymology, identify the modified proteins, and study how the modification affects protein structure/function and thus the biological significance of the modification. We also develop small molecule inhibitors to target these enzymes and investigate their potentials in treating human diseases, such as cancer.

Courses

Publications