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David B. Collum

Betty R. Miller Professor

Baker Laboratory, Room 482

dbc6@cornell.edu
607-255-4879

Educational Background

  • PhD, Columbia University
  • MS, Columbia University
  • MA, Columbia University
  • BS, Cornell University

Website(s)

Overview

The Collum group studies how aggregation and solvation dictate the reactivity and selectivity of organolithium compounds commonly used by synthetic chemists in both academia and the pharmaceutical industry. A combination of spectroscopic, kinetic, and computational methods bridge organic, organometallic, and analytical chemistry. 

Keywords

Physical organic chemistry, organolithium chemistry, kinetics and reaction mechanism

Departments/Programs

  • Chemistry and Chemical Biology

Graduate Fields

  • Chemistry and Chemical Biology

Research

The importance of organolithium reagents in organic chemistry is indisputable. Reports of the effects of solvents, reaction temperatures, additives, internal coordinating functionalities, electrophile structures, and substituents on product distributions pervade the literature. Nevertheless, complexities resulting from aggregation and solvation render our understanding of the origins of the reactivities and selectivities limited at best. Our group investigates the structural and mechanistic basis of selectivity using a range of spectroscopic, kinetic, and computational methods. A number of projects are in collaboration with pharmaceutical process groups.

Courses

Publications