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Bruce Ganem

Franz and Elisabeth Roessler Professor

Baker Laboratory, Room 332

Educational Background

  • NIH Postdoc, Stanford
  • PhD, Columbia University
  • BA, Harvard University


A synthetic organic chemist by training, Dr. Ganem has broad scientific research interests ranging from organic and analytical chemistry to biochemistry.   


  • Chemistry and Chemical Biology

Graduate Fields

  • Chemistry and Chemical Biology


  • Synthetic organic chemistry, natural products synthesis
  • New synthetic methodology, multicomponent reactions
  • Drug discovery and development
  • Biochemistry, molecular medicine. 



C. A. Simoneau, A. M. Strohl, B. Ganem, “A Novel, One-Pot Synthesis of Polysubstituted Indoles from Aliphatic Nitro Compounds,” Tetrahedron Lett. 48, 1809 (2007).

 Ganem, B. “Strategies for Innovation in Multicomponent Reaction Design,” Acc. Chem. Res. 42, 463 (2009).

 J. M. Oaksmith, B. Ganem, “Synthesis of a COMC-Estradiol Conjugate for Targeted, Tissue-selective Cancer Chemotherapy.” Tetrahedron Lett. 50, 3497 (2009).

 L. Fan, R. W. Lewis, G. P. Hess, B. Ganem, “A New Synthesis of Caged GABA Compounds for Studying GABAA Receptors,” Bioorg. Med. Chem. Lett. 19, 3932 (2009).

 H. V. Le, L. Fan, B. Ganem, “A Practical and Inexpensive ‘Convertible’ Isonitrile for Use in Multicomponent Reactions,” Tetrahedron Lett. 52, 2209 (2011).

 H. V. Le, B. Ganem, “Mild Oxidation of Tosylmethylisocyanide to Tosylmethylisocyanate: Utility in Synthetic and Medicinal Chemistry,” Tetrahedron Lett. 55, 2003 (2014).