Secrets of a radically different enzyme revealed

April 30, 2018

A team of researchers at Cornell and Northwestern have uncovered how a class of iron-sulfur cluster-containing radical S-adenosylmethionine (SAM) enzymes carry out challenging chemical reactions. This work was recently published in Science and represents a large-scale collaboration between research groups led by Hening Lin (HHMI and Cornell), Steve Ealick (Cornell), Brian Hoffman (Northwestern), Jack Freed (Cornell), and Kyle Lancaster (Cornell). Dr. Min Dong, a research associate in the Lin lab, was the lead author, and the research was supported by grants from NIH/NIGMS and DOE.

Radically Different Enzymes