Assistant Professor Nozomi Ando has received a five-year Faculty Early Career Development (CAREER) Award from the National Science Foundation (NSF) Division of Molecular and Cellular Bioscience to investigate “Correlated Motions in Protein Allostery.” According to the NSF website, "[the CAREER Program] offers the National Science Foundation's most prestigious awards in support of early-career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization." Details on this award as well as Ando's abstract (copied below) can be found in NSF awards.
Abstract: Enzymatic activity is tightly regulated so that cellular resources are not wasted by the production of unnecessary components. Allostery is a common mechanism of enzyme regulation that involves sensing whether a modulator is bound at a site distinct from the site of catalysis. The information that the modulator is present must be transmitted through correlated motions to the active site, where depending on the function of the modulator, catalytic activity is either stimulated or inhibited. The goal of this project is to understand the correlated motions that give rise to protein allostery and relate them to protein sequence. To do this, the project will take an unprecedented approach that interfaces advanced X-ray scattering methods with complementary techniques, such as single-particle cryo-electron microscopy, and computational bioinformatics. An integral part of this project is to develop a modern structural biology course that incorporates active learning techniques to equip students with the technical knowledge needed to tackle compelling, interdisciplinary problems of the future.
For more information about the research in the Ando laboratory, please visit the Ando Group Website.