The Lewis Group is engaged in the synthesis of complex natural products and the design of new catalysts to enable new bond disconnections in organic chemistry.
The synthesis of complex natural products and the discovery of methods enabling access to such molecules remain at the forefront of synthetic organic chemistry. Nature provides an endless array of complexity and bioactivity that inspires chemists to develop new strategies to meet these challenges. Research in the Lewis laboratory will encompass a broad spectrum of topics that include total synthesis of rare natural products, method development for new bond disconnections and emulation of Nature's enzymes and reactivity.
I. B. Seiple, S. Su, I. S. Young, C. A. Lewis, J. Yamaguchi, P. S. Baran. "Total Synthesis of Palau'amine", Angew. Chem. Int. Ed., 2010, Early View.
C. A. Lewis, K. E. Longcore, S. J. Miller, P. A. Wender. "An Approach to the Site-Selective Diversification of Apoptolidin A with Peptide-Based Catalysts" J. Nat. Prod., 2009, 72, 1864-1869.
T. Newhouse, C. A. Lewis, P. S. Baran. "Enantiospecific Total Syntheses of Kapakahines B and F", J. Am. Chem. Soc., 2009, 131, 6360-6361.
C. A. Lewis, J. Merkel, S. J. Miller. "Catalytic Site-selective Synthesis and Evaluation of a Series of Erythromycin Analogs," Bioorg. Med. Chem. Lett. 2008, 18, 6007-6011.
C. A. Lewis, J. L. Gustafson, A. Chiu, J. Balsells, D. Pollard, J. Murry, R. A. Reamer, K. B. Hansen, S. J. Miller. "Case of Remote Asymmetric Induction in the Peptide-Catalyzed Desymmetrization of a Bis(phenol)," J. Am. Chem. Soc. 2008, 130, 16358-16365.
C. A. Lewis, A. Chiu, M. Kubryk, J. Balsells, D. Pollard, C. K. Esser, J. Murry, R. A. Reamer, K. B. Hansen, S. J. Miller. "Remote Desymmetrization at Near-Nanometer Group Separation Catalyzed by a Miniturized Enzyme Mimic," J. Am. Chem. Soc. 2006, 128, 16454-16455. Also see "Research Highlights" Nature, 2006, 444, 974-975.
C. A. Lewis, S. J. Miller. "Site-selective Derivatization and Remodeling of Erythromycin A by Using Simple Peptide-Based Chiral Catalysts." Angew. Chem. Int. Ed. 2006, 45, 5616-5619. Also see "Editor's Choice" Science, 2006, 313, 592-593.